dSort-Seq – deep-learning–assisted high-throughput profiling of gene expression characteristics with high precision
Owing to the nondeterministic and nonlinear nature of gene expression, the steady-state intracellular protein abundance…
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COMPLETE-seq – profiling of repetitive RNA sequences in the blood plasma of patients with cancer
Liquid biopsies provide a means for the profiling of cell-free RNAs secreted by cells throughout…
PRO-IP-seq – tracks molecular modifications of engaged Pol II complexes at nucleotide resolution
RNA Polymerase II (Pol II) is a multi-subunit complex that undergoes covalent modifications as transcription…
DAESC – differential allelic expression using single-cell data
Differential allele-specific expression (ASE) is a powerful tool to study context-specific cis-regulation of gene expression.…
New technique could help make precision medicine more widely available
Simple CUT&Tag adaptation gives information about genetic regulatory elements in formalin-fixed tumor samples Formalin-fixed, paraffin-embedded…
INVADEseq – invasion adhesion directed expression sequencing
Single-cell RNA sequencing (scRNAseq) technologies have been beneficial in revealing and describing cellular heterogeneity within…
Establishment of a hybridoma sequencing pipeline for sequencing of antibody variable regions
The Neuroscience Monoclonal Antibody Sequencing Initiative (NeuroMabSeq) is a concerted effort to determine and make…
NVIGEN pioneers breakthrough in high-resolution tissue RNA sequencing with magnetic nanoparticle capture
NVIGEN, a leading provider of modern nanoparticle solutions to empower revolutionary personalized healthcare, announces its…
RNA folding studies by tRNA structure-seq inside peptide-rich droplets reveal roles of modified nucleosides at the origin of life
New research in model protocells reveals naturally occurring chemical modifications to RNA molecules help them…
AAV-Perturb-seq – adeno-associated virus (AAV)-mediated direct in vivo single-cell CRISPR screening
The ever-growing compendium of genetic variants associated with human pathologies demands new methods to study…