RNA folding studies by tRNA structure-seq inside peptide-rich droplets reveal roles of modified nucleosides at the origin of life
New research in model protocells reveals naturally occurring chemical modifications to RNA molecules help them…
Browsing: Publications
GiRAFR – gRNA detection and annotation in single-cell CRISPR screens
Novel methods that combine single cell RNA-seq with CRISPR screens enable high-throughput characterization of transcriptional…
RNA sequencing reaveals novel intracellular signaling mechanisms that promote melanoma growth
The image shows a whole mount of human epidermis including the entire thickness from basal…
AAV-Perturb-seq – adeno-associated virus (AAV)-mediated direct in vivo single-cell CRISPR screening
The ever-growing compendium of genetic variants associated with human pathologies demands new methods to study…
capTEs – Cas9-assisted profiling transposable elements expression sequencing
Transposable elements (TEs) serve as both insertional mutagens and regulatory elements in cells, and their…
eSPET-seq – genome-wide probing of eukaryotic nascent RNA structure
The transcriptional intermediates of RNAs fold into secondary structures with multiple regulatory roles, yet the…
VAX-seq – mRNA vaccine quality analysis using RNA sequencing
The success of mRNA vaccines has been realised, in part, by advances in manufacturing that…
Single-cell RNA-sequencing integration analysis revealed immune cell heterogeneity in five human autoimmune diseases
Autoimmune diseases are a group of diseases caused by abnormal immune responses to functional body…
Tasmanian tiger RNA is first to be recovered, sequenced from an extinct animal
A new study shows the isolation and sequencing of more than a century-old RNA molecules…
“CHOOSE” – CRISPR-human organoids-scRNA-seq
Does the human brain have an Achilles heel that ultimately leads to Autism? With a…