eSPET-seq – genome-wide probing of eukaryotic nascent RNA structure
The transcriptional intermediates of RNAs fold into secondary structures with multiple regulatory roles, yet the…
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VAX-seq – mRNA vaccine quality analysis using RNA sequencing
The success of mRNA vaccines has been realised, in part, by advances in manufacturing that…
“CHOOSE” – CRISPR-human organoids-scRNA-seq
Does the human brain have an Achilles heel that ultimately leads to Autism? With a…
M3-seq – single-cell massively-parallel multiplexed microbial sequencing
Three Princeton laboratories teamed up to develop a method for studying gene expression patterns of…
A targeted sequencing extension for transcript genotyping in single-cell transcriptomics
As no existing methods within the single-cell RNA sequencing repertoire combine genotyping of specific genomic…
nanoSPLITS – parallel measurement of transcriptomes and proteomes from same single cells
Single-cell multiomics can provide comprehensive insights into gene regulatory networks, cellular diversity, and temporal dynamics.…
COMPLETE-seq – noncoding RNA liquid biopsy platform improves cancer detection
A novel liquid biopsy technology developed by Assistant Professor of Biomolecular Engineering Daniel Kim’s lab…
sNucConv – a bulk RNA-seq deconvolution method trained on single-nucleus RNA-seq data to estimate cell-type composition
Deconvolution algorithms rely on single-cell RNA-sequencing (scRNA-seq) data applied onto bulk RNA-sequencing (bulk RNA-seq) to…
Joint-snhmC-seq – simultaneously profile 5hmC and true 5mC in single cells
Oxidative modification of 5-methylcytosine (5mC) by ten-eleven translocation (TET) DNA dioxygenases generates 5-hydroxymethylcytosine (5hmC), the…
SLAM-Drop-seq reveals mRNA kinetic rates throughout the cell cycle
RNA abundance is tightly regulated in eukaryotic cells by modulating the kinetic rates of RNA…