AAV-Perturb-seq – adeno-associated virus (AAV)-mediated direct in vivo single-cell CRISPR screening
The ever-growing compendium of genetic variants associated with human pathologies demands new methods to study…
Browsing: Publications
capTEs – Cas9-assisted profiling transposable elements expression sequencing
Transposable elements (TEs) serve as both insertional mutagens and regulatory elements in cells, and their…
eSPET-seq – genome-wide probing of eukaryotic nascent RNA structure
The transcriptional intermediates of RNAs fold into secondary structures with multiple regulatory roles, yet the…
VAX-seq – mRNA vaccine quality analysis using RNA sequencing
The success of mRNA vaccines has been realised, in part, by advances in manufacturing that…
Single-cell RNA-sequencing integration analysis revealed immune cell heterogeneity in five human autoimmune diseases
Autoimmune diseases are a group of diseases caused by abnormal immune responses to functional body…
Tasmanian tiger RNA is first to be recovered, sequenced from an extinct animal
A new study shows the isolation and sequencing of more than a century-old RNA molecules…
“CHOOSE” – CRISPR-human organoids-scRNA-seq
Does the human brain have an Achilles heel that ultimately leads to Autism? With a…
Aging is associated with a systemic transcriptome imbalance
Newly uncovered mechanism holds true across a variety of animals, including humans Northwestern University…
M3-seq – single-cell massively-parallel multiplexed microbial sequencing
Three Princeton laboratories teamed up to develop a method for studying gene expression patterns of…
New large TWAS study finds new genetic susceptibilities for colon cancer
Researchers at Vanderbilt-Ingram Cancer Center have found new genes that put people at higher risk…