Single-cell RNA sequencing derived immune atlas at cell level points to new combination treatment for incurable childhood cancer
A detailed ‘atlas’ of neuroblastoma tumors points to a new target for immunotherapy. Scientists from…
Browsing: Publications
sc-SPORT – RNA structure profiling at single-cell resolution
RNA structure is critical for multiple steps in gene regulation. However, how the structures of…
Advancing single-cell RNA-seq data analysis through the fusion of multi-layer perceptron and graph neural network
The advancement of single-cell sequencing technology has smoothed the ability to do biological studies at…
Scientists unveil first complete cellular map of adult mouse brain
High-resolution atlas charts neural neighborhoods for more than 5,300 cell types Six years and 32…
Droplet-based glycan and RNA sequencing for profiling the distinct cellular glyco-states in single cells
Plate-based single-cell glycan and RNA sequencing (scGR-seq) is previously developed to realize the integrated analysis…
RENGE infers gene regulatory networks using time-series single-cell RNA-seq data with CRISPR perturbations
Single-cell RNA-seq analysis coupled with CRISPR-based perturbation has enabled the inference of gene regulatory networks…
SUM-seq – scalable ultra-high-throughput single-cell chromatin and RNA sequencing
Enhancers and transcription factors (TFs) are crucial in regulating cellular processes, including disease-associated cell states.…
Transcriptomics data can be integrated to derive a holistic representation of the phenotypic heterogeneity of the TME
The cellular and molecular heterogeneity of tumors is a major obstacle to cancer immunotherapy. Here,…
scAN1.0 – a reproducible and standardized pipeline for processing 10X single cell RNAseq data
Single cell transcriptomics has recently seen a surge in popularity, leading to the need for…
The hidden power of intracellular neighborhoods
Back in 2018, the lab of Christine Mayr, MD, PhD, at Memorial Sloan Kettering Cancer Center…