MapUTR – identifies rare functional 3′ UTR variants regulating mRNA abundance of cancer driver genes
Understanding the function of rare non-coding variants has long been a daunting task. These elusive…
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MUSIC – multinucleic acid interaction mapping in single cells
Chromatin, the complex of DNA and proteins, plays a central role in orchestrating gene expression…
Microwell-seq3 – fast and flexible profiling of chromatin accessibility and total RNA expression in single nuclei
Advancements in single-cell genomics have revolutionized our understanding of cell diversity and function in complex…
NAP-seq reveals multiple classes of structured noncoding RNAs with regulatory functions
The human genome is a vast landscape of genetic information, but much of it remains…
One-pot method for preparing DNA, RNA, and protein for multiomics analysis
Unraveling the complexities of diseases such as cancer often requires a multi-faceted approach, analyzing various…
CLiPPR-Seq – global identification of mRNA-interacting circular RNAs
Circular RNA (circRNA) has garnered considerable attention in recent years due to its regulatory roles…
Artificial spike-ins could improve accuracy of plant RNA-seq analysis
Researchers at NC State have published a simple trick that improves the accuracy of techniques…
BOLT-seq – cost and time-efficient construction of a 3′-end mRNA library from unpurified bulk RNA in a single tube
Unraveling the transcriptome—the complete set of RNA molecules in a cell—is pivotal for understanding gene…
Single-molecule RNA sizing enables quantitative analysis of alternative transcription termination
Transcription, the process of synthesizing RNA from DNA, lies at the heart of molecular biology…
TSS-seq2 – an improved method for the highly specific detection of transcription start sites
Understanding gene transcription—the process by which genetic information encoded in DNA is converted into RNA—is…