sbRNA-seq – semibulk RNA-seq analysis for measuring gene expression statuses in a local cellular environment
When biologically interpretation of the data obtained from the single-cell RNA sequencing (scRNA-seq) analysis is…
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CH-seq – single-cell combinatorial hybridization sequencing
In recent years, high-throughput single-cell transcriptomics and chromatin accessibility methods have generated numerous resources and…
snPATHO-seq – unlocking the FFPE archives for single nucleus RNA profiling
FFPE (formalin-fixed, paraffin-embedded) tissue archives are the largest repository of clinically annotated human specimens. Despite…
A potent new tool combining mass spectrometry data with long-read RNA sequencing to advance medical research
University of Virginia School of Medicine researchers and their collaborators have created a powerful new…
smStructure-seq reveals how environmental changes affect the shapes of RNA in living cells
The impact of environmental conditions on the dynamic structures of RNAs in living cells has…
Spatial-ATAC-seq – spatially resolved chromatin accessibility profiling of tissue sections
Cellular function in tissue is dependent on the local environment, requiring new methods for spatial…
TGIRT sequencing reveals abundant non-microRNA-small RNAs in BLCA tumor samples
Bladder cancer (BLCA) is one of the most common cancer types worldwide. The disease is…
Sample-multiplexing approaches for single-cell sequencing
Single-cell sequencing is widely used in biological and medical studies. However, its application with multiple…
DeLTa-Seq – direct-lysate targeted RNA-Seq from crude tissue lysate
Quantification of gene expression such as RNA-Seq is a popular approach to study various biological…
BacDrop – droplet-based single-cell RNA-seq reveals heterogeneity in bacterial populations and in response to antibiotic perturbation
Broad Institute researchers have developed BacDrop, a highly scalable technology for bacterial single-cell RNA sequencing…