HIT-scISOseq – high-throughput and high-accuracy single-cell RNA isoform analysis using PacBio circular consensus sequencing
Although long-read single-cell RNA isoform sequencing (scISO-Seq) can reveal alternative RNA splicing in individual cells,…
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PSCSR-seq – parallel single-cell small RNA sequencing
miRNA and other forms of small RNAs are known to regulate many biological processes. Single-cell…
dd-scCNV Seq – digital microfluidics-based digital counting of single-cell copy number variation
Single-cell copy number variations (CNVs), major dynamic changes in humans, result in differential levels of…
scEC&T-seq – parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells
Extrachromosomal DNAs (ecDNAs) are common in cancer, but many questions about their origin, structural dynamics…
TEMPOmap – a method that uncovers subcellular RNA profiles across time and space at the single-cell level
TEMPOmap can follow thousands of newly made RNA molecules within a cell simultaneously, revealing new…
Nano-tRNAseq – quantitative analysis of tRNA abundance and modifications by nanopore RNA sequencing
Transfer RNAs (tRNAs) play a central role in protein translation. Studying them has been difficult…
Researchers have developed an instrument-free single-cell RNA sequencing using a reversible hydrogel for cell-specific barcoding
Researchers at Scipio Bioscience report progress in sample preparation for scRNA-seq based on RevGel-seq, a…
Learning to predict RNA sequence expressions from whole slide images
Deep learning methods are widely applied in digital pathology to address clinical challenges such as…
CRIC-seq – global profiling of in-situ RNA–RNA contacts associated with a specific RNA-binding protein
A research team led by Prof. XUE Yuanchao from the Institute of Biophysics of the Chinese Academy…
SiT – spatial isoform transcriptomics
In situ capturing technologies add tissue context to gene expression data, with the potential of…