AS-CMC – a pan-cancer database of alternative splicing for molecular classification of cancer
Alternative splicing (AS) is a post-transcriptional regulation that leads to the complexity of the transcriptome.…
Browsing: Publications
scPolyA-seq – comprehensive mapping of alternative polyadenylation site usage and its dynamics at single-cell resolution
Alternative polyadenylation (APA) plays an important role in posttranscriptional gene regulation such as transcript stability…
DeepVelo – single-cell transcriptomic deep velocity field learning with neural ordinary differential equations
Recent advances in single-cell sequencing technologies have provided unprecedented opportunities to measure the gene expression…
Improved bacterial single-cell RNA-seq
Bulk RNA-sequencing technologies have provided invaluable insights into host and bacterial gene expression and associated…
The mystery of the origins of introns solved
UCSC scientists point to introners as the source of the vast majority of introns, a…
Mapping single-cell transcriptomes in the intra-tumoral and associated territories of kidney cancer
Tumor behavior is intricately dependent on the oncogenic properties of cancer cells and their multi-cellular…
RNAmp – directly measure widespread hypertranscription in aggressive human cancers
Cancers are often defined by the dysregulation of specific transcriptional programs; however, the importance of…
Single-cell RNA-sequencing data analysis reveals transcriptional response to SARS-CoV-2 infection
Single-cell RNA sequencing (scRNA-seq) is currently one of the most powerful techniques available to study…
SMS-seq – long-read single-molecule RNA structure sequencing using nanopore
RNA molecules can form secondary and tertiary structures that can regulate their localization and function.…
Researchers established a framework to streamline single-cell RNA-seq analysis of the heterogeneous tumor microenvironment
With development of many effective approaches to fighting cancer, the focus becomes less about finding…