Single-nuclei characterization of pervasive transcriptional signatures across organs in response to COVID-19
Infection by coronavirus SARS-CoV2 is a severe and often deadly disease that has implications for…
Browsing: Publications
BENGAL – benchmarking strategies for cross-species integration of single-cell RNA sequencing data
The growing number of available single-cell gene expression datasets from different species creates opportunities to…
Single-cell analysis of prenatal and postnatal human cortical development
Cortical development in humans is a meticulously regulated process that unfolds over months of prenatal…
The Human Breast Cell Atlas – world’s most comprehensive single-cell atlas of healthy breast tissue
The Human Breast Cell Atlas, recently published in Nature, is a landmark achievement for mammary biology…
Population-level integration of single-cell datasets enables multi-scale analysis across samples
The increasing amount of data recorded in medical research can only lead to scientific breakthroughs…
Bulk and single-cell RNA-seq data reveal what potentially causes a leukemia to become more aggressive
Scientists with City of Hope®, one of the largest cancer research and treatment organizations in…
DAESC – differential allelic expression using single-cell data
Differential allele-specific expression (ASE) is a powerful tool to study context-specific cis-regulation of gene expression.…
FWP – feature-weight based measurement of cancerous transcriptome using cohort-wide and sample-specific information
Identifying cancerous samples or cells using transcriptomic data is critical for cancer related basic research,…
Single-cell transcriptomic atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer’s disease pathology
Alzheimer’s disease (AD) is the most common cause of dementia worldwide, but the molecular and…
DeepCCI – a deep learning framework for identifying cell–cell interactions from single-cell RNA sequencing data
Cell-cell interactions (CCIs) play critical roles in many biological processes such as cellular differentiation, tissue…