Integrating single-cell imaging and RNA sequencing datasets links differentiation and morphogenetic dynamics
Basic helix-loop-helix genes, particularly proneural genes, are well-described triggers of cell differentiation, yet information on…
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scCARE-seq – simultaneous profiling of chromatin architecture and transcription in single cells
The three-dimensional structure of chromatin plays a crucial role in development and disease, both of…
Stem cell-derived organoids secrete tooth enamel proteins
The advance is seen as a critical first step toward novel treatments to repair and…
New RNA sequencing technique illuminates how abnormal RNA splicing leads to disease
Blood smear from an adult female with myelodysplastic syndrome. Credit: The Armed Forces Institute of Pathology…
Researchers use RNA-Seq to investigate link between “deprogrammed” regulatory T cells and cardiovascular disease
Scientists can finally hunt down a harmful kind of human T cell, thanks to new…
MSIQ -joint modeling of multiple RNA-seq samples for accurate isoform quantification
Next-generation RNA sequencing (RNA-seq) technology has been widely used to assess full-length RNA isoform abundance…
Single-cell RNA sequencing identifies how brain cells of males and females respond differently to chronic stress
A new study in mice could pave the way to personalized therapy for depression, anxiety…
TEQUILA-seq – a versatile and low-cost method for targeted long-read RNA sequencing
Long-read RNA sequencing (RNA-seq) is a powerful technology for transcriptome analysis, but the relatively low…
CellBender – unsupervised removal of systematic background noise from droplet-based single-cell experiments
Droplet-based single-cell assays, including single-cell RNA sequencing (scRNA-seq), single-nucleus RNA sequencing (snRNA-seq) and cellular indexing…
spinDrop – a droplet microfluidic platform to maximise single-cell sequencing information content
Droplet microfluidic methods have massively increased the throughput of single-cell sequencing campaigns. The benefit of…