Perturb-Multimodal – a platform for pooled genetic screens with imaging and sequencing in intact mammalian tissue

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Scientists at the Howard Hughes Medical Institute have created a powerful new tool called Perturb-Multimodal, or Perturb-Multi for short. This innovative method helps researchers explore how genes control the behavior and function of individual cells within complex tissues, like the liver.Every living organism, from tiny animals to humans, depends on thousands of genes working …

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