Single-nuclei RNA sequencing (snRNA-seq) is a powerful tool for studying gene expression in individual nuclei, providing crucial insights into complex biological systems. However, the technique often struggles with a significant issue: background noise. Contamination from empty droplets or debris can obscure the true gene activity specific to different cell types, complicating analysis and risking …
QClus – a droplet filtering algorithm for enhanced snRNA-seq data quality in challenging samples
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