snPATHO-seq – a versatile FFPE single-nucleus RNA sequencing method to unlock pathology archives
Formalin-fixed paraffin-embedded (FFPE) samples are widely used in biomedical research, especially in pathology. These samples…
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scNanoSeq-CUT&Tag – single-cell long-read sequencing method for chromatin modification profiling
A significant aspect of gene regulation is the structure of chromatin, which is a combination…
BACS – absolute quantitative and base-resolution sequencing reveals comprehensive landscape of pseudouridine across the human transcriptome
Pseudouridine (Ψ) is a common modification found in RNA, the molecule that plays a vital…
SPEAC-seq – droplet-based functional CRISPR screening of cell–cell interactions
Cell-to-cell communication is vital for the proper functioning of tissues in our bodies. Every action,…
Use of synthetic circular RNA spike-ins (SynCRS) for normalization of circular RNA sequencing data
High-throughput RNA sequencing has revolutionized how scientists study gene expression, enabling us to measure the…
scRICA-seq – simultaneous profiling of RNA isoforms and chromatin accessibility of single cells
Researchers at Sun Yat-Sen University have made an exciting breakthrough in understanding how neurons develop,…
DORQ-seq – high-throughput quantification of femtomol tRNA pools by combination of cDNA hybridization and deep sequencing
Transfer RNAs (tRNAs) are critical molecules involved in protein synthesis, but they can be tough…
Using wastewater RNA sequencing to identify and track new covid-19 variants
RNA sequencing has become an essential tool in tracking the spread and evolution of COVID-19,…
Overcoming nucleotide bias in the nonenzymatic copying of RNA templates
The RNA World Hypothesis suggests that early in the development of life, RNA played a…
PIP-seq – particle-templated instant partition sequencing
Understanding how our immune cells respond to different environmental factors is key to developing better…