Challenges and perspectives in applying single nuclei RNA-seq technology in plant biology
Plant single-cell RNA-seq technology quantifies the abundance of plant transcripts at a single-cell resolution. Deciphering…
Browsing: Review Publications
Impact of the Human Cell Atlas on medicine
Single-cell atlases promise to provide a ‘missing link’ between genes, diseases and therapies. By identifying…
Data analysis guidelines for single-cell RNA-seq in biomedical studies and clinical applications
The application of single-cell RNA sequencing (scRNA-seq) in biomedical research has advanced our understanding of…
Single-cell sequencing – promises and challenges for human genetics
Over the last decade, single-cell sequencing has transformed many fields. It has enabled the unbiased…
Exosome RNA sequencing as a tool in the search for cancer biomarkers
Numerous noninvasive methods are currently being used to determine biomarkers for diseases such as cancer.…
An up-to-date overview of scRNA-seq data generation and analysis
Single cell RNA sequencing (scRNA-seq) is today a common and powerful technology in biomedical research…
Challenges of single-cell and single-nucleus RNA-sequencing from core needle biopsy specimens
Single-cell RNA sequencing (scRNA-seq) and single-nucleus RNA-seq (snRNA-seq) allow transcriptomic profiling of thousands of cells…
A simple guide to de novo transcriptome assembly and annotation
A transcriptome constructed from short-read RNA sequencing (RNA-seq) is an easily attainable proxy catalog of…
The emerging landscape of spatial profiling technologies
Improved scale, multiplexing and resolution are establishing spatial nucleic acid and protein profiling methods as…
Current statistical approaches and outstanding challenges to differential expression analysis of single-cell RNA-seq data
With the advent of single-cell RNA-sequencing (scRNA-seq), it is possible to measure the expression dynamics…