Challenges of single-cell and single-nucleus RNA-sequencing from core needle biopsy specimens
Single-cell RNA sequencing (scRNA-seq) and single-nucleus RNA-seq (snRNA-seq) allow transcriptomic profiling of thousands of cells…
Browsing: Review Publications
A simple guide to de novo transcriptome assembly and annotation
A transcriptome constructed from short-read RNA sequencing (RNA-seq) is an easily attainable proxy catalog of…
The emerging landscape of spatial profiling technologies
Improved scale, multiplexing and resolution are establishing spatial nucleic acid and protein profiling methods as…
Current statistical approaches and outstanding challenges to differential expression analysis of single-cell RNA-seq data
With the advent of single-cell RNA-sequencing (scRNA-seq), it is possible to measure the expression dynamics…
Advances in single-cell multiomic profiling
Single-cell transcriptomic approaches have revolutionised the study of complex biological systems, with the routine measurement…